N. painfulness, trouble, care, trial, affliction, infliction, blow, stroke, burden, load, curse, bitter pill, bitter draught, waters of bitterness, annoyance, grievance, nuisance, vexation, mortification, sickener, bore, bother, pother, hot water, "sea of troubles", hornet's nest, plague, pest, cancer, ulcer, sting, thorn, canker, scorpion, dagger, scourge, carking care, canker worm of care, mishap, misfortune, desagrement, esclandre, rub, source of irritation, source of annoyance, wound, open sore, sore subject, skeleton in the closet, thorn in the flesh, thorn in one's side, where the shoe pinches, gall and wormwood, sorry sight, heavy news, provocation, affront, "head and front of one's offending", infestation, molestation, malignity

V. cause pain, occasion pain, give pain, bring pain, induce pain, produce pain, create pain, inflict pain, pain, hurt, wound, pinch, prick, gripe, pierce, lancinate, cut, hurt the feelings, wound the feelings, grate upon the feelings, grate upon the nerves, jar upon the feelings, wring the heart, pierce the heart, lacerate the heart, break the heart, rend the heart, make the heart bleed, tear the heart strings, rend the heart strings, draw tears from the eyes, sadden, make unhappy, plunge into sorrow, grieve, fash, afflict, distress, cut up, cut to the heart, displease, annoy, incommode, discompose, trouble, disquiet, faze, feaze, feeze (u .s.), disturb, cross, perplex, molest, tease, tire, irk, vex, mortify, wherret|, worry, plague, bother, pester, bore, pother, harass, harry, badger, heckle, bait, beset, infest, persecute, importune, wring, harrow, torment, torture, bullyrag, put to the rack, put to the question, break on the wheel, rack, scarify, cruciate, crucify, convulse, agonize, barb the dart, plant a dagger in the breast, plant a thorn in one's side, irritate, provoke, sting, nettle, try the patience, pique, fret, rile, tweak the nose, chafe, gall, sting to the quick, wound to the quick, cut to the quick, aggrieve, affront, enchafe, enrage, ruffle, sour the temper, give offense, maltreat, bite, snap at, assail, smite, sicken, disgust, revolt, nauseate, disenchant, repel, offend, shock, stink in the nostrils, go against the stomach, turn the stomach, make one sick, set the teeth on edge, go against the grain, grate on the ear, stick in one's throat, stick in one's gizzard, rankle, gnaw, corrode, horrify, appal, appall, freeze the blood, make the flesh creep, make the hair stand on end, make the blood curdle, make the blood run cold, make one shudder, haunt the memory, weigh on the heart, prey on the heart, weigh on the mind, prey on the mind, weigh on the spirits, prey on the spirits, bring one's gray hairs with sorrow to the grave, add a nail to one's coffin

Adj. causing pain, hurting, hurtful, painful, dolorific, dolorous, unpleasant, unpleasing, displeasing, disagreeable, unpalatable, bitter, distasteful, uninviting, unwelcome, undesirable, undesired, obnoxious, unacceptable, unpopular, thankless, unsatisfactory, untoward, unlucky, uncomfortable, distressing, afflicting, afflictive, joyless, cheerless, comfortless, dismal, disheartening, depressing, depressive, dreary, melancholy, grievous, piteous, woeful, rueful, mournful, deplorable, pitiable, lamentable, sad, affecting, touching, pathetic, irritating, provoking, stinging, annoying, aggravating, mortifying, galling, unaccommodating, invidious, vexatious, troublesome, tiresome, irksome, wearisome, plaguing, plaguy, awkward, importunate, teasing, pestering, bothering, harassing, worrying, tormenting, carking, intolerable, insufferable, insupportable, unbearable, unendurable, past bearing, not to be borne, not to be endured, more than flesh and blood can bear, enough to drive one mad, enough to provoke a saint, enough to make a parson swear, enough to gag a maggot, shocking, terrific, grim, appalling, crushing, dreadful, fearful, frightful, thrilling, tremendous, dire, heart-breaking, heart-rending, heart-wounding, heart-corroding, heart-sickening, harrowing, rending, odious, hateful, execrable, repulsive, repellent, abhorrent, horrid, horrible, horrific, horrifying, offensive, nauseous, nauseating, disgusting, sickening, revolting, nasty, loathsome, loathful, fulsome, vile, hideous, sharp, acute, sore, severe, grave, hard, harsh, cruel, biting, caustic, cutting, corroding, consuming, racking, excruciating, searching, grinding, grating, agonizing, envenomed, catheretic, pyrotic, ruinous, disastrous, calamitous, tragical, desolating, withering, burdensome, onerous, oppressive, cumbrous, cumbersome

Adv. painfully, with pain, deuced

Int. hinc illae lachrymae, phr, surgit amari aliquid, the place being too hot to hold one, the iron entering into the soul, "he jests at scars that never felt a wound", "i must be cruel only to be kind", "what deep wounds ever closed without a scar?"

N. dejection, dejectedness, depression, prosternation|, lowness of spirits, depression of spirits, weight on the spirits, oppression on the spirits, damp on the spirits, low spirits, bad spirits, drooping spirits, depressed spirits, heart sinking, heaviness of heart, failure of heart, heaviness, infestivity, gloom, weariness, taedium vitae, disgust of life, mal du pays, anhedonia, melancholy, sadness, il penseroso, melancholia, dismals, blues, lachrymals, mumps, dumps, blue devils, doldrums, vapors, megrims, spleen, horrors, hypochondriasis, pessimism, la maladie sans maladie, despondency, slough of despond, disconsolateness, hope deferred, blank despondency, voiceless woe, prostration of soul, broken heart, despair, cave of despair, cave of trophonius demureness, gravity, solemnity, long face, grave face, hypochondriac, seek sorrow, self-tormentor, heautontimorumenos, malade imaginaire, medecin tant pis, croaker, pessimist, mope, mopus, affliction, sorry sight, memento mori, damper, wet blanket, job's comforter

V. be dejected, grieve, mourn, take on, give way, lose heart, despond, droop, sink, lower, look downcast, frown, pout, hang down the head, pull a long face, make a long face, laugh on the wrong side of the mouth, grin a ghastly smile, look blue, look like a drowned man, lay to heart, take to heart, mope, brood over, fret, sulk, pine, pine away, yearn, repine, despair, refrain from laughter, keep one's countenance, be grave, look grave, repress a smile, depress, discourage, dishearten, dispirit, damp, dull, deject, lower, sink, dash, knock down, unman, prostrate, break one's heart, frown upon, cast a gloom, cast a shade on, sadden, damp one's hopes, dash one's hopes, wither one's hopes, weigh on the mind, lie heavy on the mind, prey on the mind, weigh on the spirits, lie heavy on the spirits, prey on the spirits, damp the spirits, depress the spirits

Adj. cheerless, joyless, spiritless, uncheerful, uncheery, unlively, unhappy, melancholy, dismal, somber, dark, gloomy, triste, clouded, murky, lowering, frowning, lugubrious, funereal, mournful, lamentable, dreadful, dreary, flat, dull, dull as a beetle, dull as ditchwater, depressing, "melancholy as a gib cat", oppressed with melancholy, a prey to melancholy, downcast, downhearted, down in the mouth, down in one's luck, heavy-hearted, in the dumps, down in the dumps, in the suds, in the sulks, in the doldrums, in doleful dumps, in bad humor, sullen, mumpish, dumpish, mopish, moping, moody, glum, sulky, out of sorts, out of humor, out of heart, out of spirits, ill at ease, low spirited, in low spirits, a cup too low, weary, discouraged, disheartened, desponding, chapfallen, chopfallen, jaw fallen, crest fallen, sad, pensive, penseroso, tristful, dolesome, doleful, woebegone, lacrymose, lachrymose, in tears, melancholic, hypped, hypochondriacal, bilious, jaundiced, atrabilious, saturnine, splenetic, lackadaisical, serious, sedate, staid, stayed, grave as a judge, grave as an undertaker, grave as a mustard pot, sober, sober as a judge, solemn, demure, grim, grim-faced, grim-visaged, rueful, wan, long-faced, disconsolate, unconsolable, inconsolable, forlorn, comfortless, desolate, desole, sick at heart, soul sick, heart sick, au desespoir, in despair, lost, overcome, broken down, borne down, bowed down, heartstricken, cut up, dashed, sunk, unnerved, unmanned, down fallen, downtrodden, broken-hearted, careworn

Adv. with a long face, with tears in one's eyes, sadly

Phr. the countenance falling, the heart failing, the heart sinking within one, "a plague of sighing and grief", "thick-ey'd musing and curs'd melancholy", "the sickening pang of hope deferred"